Differences in Colorectal Cancer Pathology Between Egyptians and Western Patients
Author Information
Author(s): Soliman A S, Bondy M L, El-Badawy S A, Mokhtar N, Eissa S, Bayoumy S, Seifeldin I A, Houlihan P S, Lukish J R, Watanabe T, Chan A On On, Zhu D, Amos C I, Levin B, Hamilton S R
Primary Institution: The University of Texas M.D. Anderson Cancer Center
Hypothesis
The molecular pathology of colorectal carcinoma differs between Egyptian and Western patients.
Conclusion
The study found unique differences in the molecular pathology of colorectal cancer between Egyptians and Western patients, with schistosomiasis influencing some tumors.
Supporting Evidence
- Most Egyptian cancers were rectal (51%) and poorly differentiated (58%).
- High levels of microsatellite instability (MSI-H) were frequent (37%).
- K-ras mutation was uncommon (11%).
- High frequencies of MSI-H in rectal carcinomas (36%) were found.
Takeaway
Doctors looked at cancer in Egyptian patients and found it can be different from what they see in Western patients, especially in younger people.
Methodology
The study compared the molecular pathology of colorectal cancer in 59 Egyptian patients to that of Western patients.
Participant Demographics
Egyptian patients aged 10–72 years.
Digital Object Identifier (DOI)
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