Effects of Cytokines on Fever and Blood Parameters in Dwarf Goats
Author Information
Author(s): C. T. M. van Duin, T. Wensing, A. S. J. P. A. M. van Miert
Primary Institution: Utrecht University
Hypothesis
The study investigates the effects of recombinant bovine interleukins and interferon on the acute phase response in dwarf goats.
Conclusion
The study found that different cytokines induce varying degrees of fever and changes in plasma zinc and iron concentrations in dwarf goats.
Supporting Evidence
- r.BoIL_l induced immediate fever peaking at 45 and 180 minutes after injection.
- r.BoIFN_ caused a delayed fever response compared to r.BoIL_l.
- Plasma zinc and iron concentrations significantly decreased after r.BoIL_l administration.
- r.BoIL_2 did not induce significant changes in plasma trace metal concentrations.
- Leukocyte counts increased after administration of r.BoIL_l and r.BoIFN_.
Takeaway
When dwarf goats were given certain proteins called cytokines, they got fevers and their blood levels of zinc and iron changed.
Methodology
Eighteen healthy dwarf goats were injected with different cytokines, and their body temperature, plasma zinc and iron levels, and white blood cell counts were measured.
Limitations
The study did not perform dose-effect titration studies due to a limited number of goats.
Participant Demographics
Eighteen healthy dwarf goats, including females and castrated males.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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