Anti-inflammatory effects of desipramine and fluoxetine
Author Information
Author(s): Caroline Roumestan, Alain Michel, Florence Bichon, Karine Portet, Maëlle Detoc, Corinne Henriquet, Dany Jaffuel, Marc Mathieu
Primary Institution: Inserm, U454, Montpellier, France
Hypothesis
Do the antidepressants desipramine and fluoxetine have anti-inflammatory properties in animal models of septic shock and allergic asthma?
Conclusion
Desipramine and fluoxetine reduce the inflammatory reaction in two animal models of human diseases.
Supporting Evidence
- Desipramine and fluoxetine significantly decreased TNF-α levels in septic shock models.
- In the septic shock model, fluoxetine reduced mortality to 50%, while controls had 90% mortality.
- Both antidepressants reduced lung inflammation in ovalbumin-sensitized rats.
- Desipramine and fluoxetine inhibited TNF-α release from LPS-treated monocytes.
Takeaway
Desipramine and fluoxetine, which are antidepressants, can help reduce inflammation in certain diseases like septic shock and asthma.
Methodology
The study used animal models to compare the effects of desipramine and fluoxetine with prednisolone on inflammation and mortality rates.
Limitations
The study was conducted in animal models, which may not fully represent human responses.
Participant Demographics
The study involved various animal models, including BALB/c mice and Brown Norway rats.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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