HAPSIMU: A Genetic Simulation Platform for Association Studies
Author Information
Author(s): Zhang Feng, Liu Jianfeng, Chen Jie, Deng Hong-Wen
Primary Institution: Xi'an Jiaotong University
Hypothesis
How can we effectively evaluate and reduce the negative impact of population structure on population-based association studies?
Conclusion
HAPSIMU provides a common genetic simulation platform to evaluate the impact of population structure on PBAS and compare various methods.
Supporting Evidence
- HAPSIMU can simulate heterogeneous populations with various known population structures.
- The platform allows for both qualitative and quantitative trait simulations.
- It outputs data in formats compatible with several existing PBAS software.
Takeaway
HAPSIMU is a tool that helps scientists understand how different populations can affect genetic studies by simulating these populations.
Methodology
Developed a genetic simulation platform based on real haplotype data to simulate heterogeneous populations under different models.
Limitations
The platform may not account for all real-world complexities in population structure.
Participant Demographics
Simulated populations include individuals of Caucasian and Yoruba descent.
Digital Object Identifier (DOI)
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