Increased Susceptibility to Arthritis in Female Mice
Author Information
Author(s): Maria Liljander, Åsa Andersson, Rikard Holmdahl, Ragnar Mattsson
Primary Institution: Lund University
Hypothesis
The Cia40/Pregq2 region of chromosome 11 may contain polymorphic genes that influence both collagen-induced arthritis (CIA) incidence and breeding success.
Conclusion
The Cia40/Pregq2 locus significantly influences both the incidence and severity of collagen-induced arthritis in female mice.
Supporting Evidence
- Heterozygous Cia40 congenic females showed a significantly higher incidence of arthritis compared to wildtype females.
- The onset of arthritis was quicker in heterozygous females than in wildtype littermates.
- Heterozygous Cia40 congenic females developed significantly higher anti-CII antibody titers than wildtype and homozygous congenic females.
- Congenic females exhibited reduced breeding performance and disturbed breeding behavior.
Takeaway
This study found that female mice with certain genetic traits are more likely to get arthritis and have trouble having babies.
Methodology
Congenic B10.Q mice were created and tested in a collagen-induced arthritis model, measuring incidence, severity, and antibody levels.
Limitations
The study primarily focused on female mice, which may limit the generalizability of the findings to males.
Participant Demographics
Inbred NFR/N and B10.Q mice were used, with a focus on female mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website