Epigenetics in Prostate Cancer Development
Author Information
Author(s): Colin Cooper, Chris Foster
Primary Institution: Institute of Cancer Research, University of Liverpool
Hypothesis
Epigenetic changes play a significant role in the development of human prostate cancer.
Conclusion
Epigenetic alterations are linked to the origin and progression of prostate cancer, providing potential diagnostic and therapeutic targets.
Supporting Evidence
- Epigenetic changes are linked to the development of prostate cancer.
- Methylation patterns can serve as biomarkers for diagnosis and prognosis.
- Histone modifications are associated with cancer prognosis.
- Small RNAs may play a role in epigenetic regulation in cancer.
Takeaway
Scientists found that changes in how genes are turned on or off, without changing the DNA itself, can help explain how prostate cancer starts and grows.
Methodology
The review summarizes evidence supporting the role of epigenetic changes in prostate cancer and discusses emerging concepts and technologies.
Limitations
The review does not conduct a systematic analysis of epigenetic changes across various cancer types.
Digital Object Identifier (DOI)
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