PGK1's Role in Sepsis and Immune Infiltration
Author Information
Author(s): Liu Yu, Li Weijie, Lei Lei, Zhou Yaoliang, Huang Mingcheng, Li Yide, Zhang Xiaoying, Jiang Yingyu, Wu Haiqi, Zheng Zhihua, Ma Kongyang, Tang Chun
Primary Institution: The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
Hypothesis
PGK1 may serve as a sensitive and specific biomarker for the diagnostic assessment of sepsis.
Conclusion
PGK1 serves as a novel diagnostic biomarker for sepsis, with potential implications for prognosis and immune regulation.
Supporting Evidence
- PGK1 was significantly upregulated in sepsis patients across multiple datasets.
- The area under the ROC curve (AUC) for PGK1 exceeded 0.9, indicating strong diagnostic potential.
- PGK1 expression correlated positively with inflammatory mediators like CXCL1 and CXCL16.
- High PGK1 expression was associated with increased memory B cells and monocytes in sepsis.
Takeaway
This study found that a protein called PGK1 is higher in people with sepsis, which could help doctors diagnose and understand the disease better.
Methodology
The study used microarray datasets and single-cell RNA sequencing to analyze PGK1 expression in sepsis patients.
Limitations
The sample size was relatively small, and further validation in larger studies is needed.
Participant Demographics
Sepsis patients from the Seventh Affiliated Hospital of Sun Yat-sen University.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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