Effects of Weight Loss in Metabolically Healthy Obese Subjects after Gastric Banding
Author Information
Author(s): Sesti Giorgio, Folli Franco, Perego Lucia, Hribal Marta Letizia, Pontiroli Antonio E.
Primary Institution: Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy
Hypothesis
Weight loss in metabolically healthy obese (MHO) subjects may result in deterioration of cardio-metabolic risk profile.
Conclusion
Weight loss from laparoscopic adjustable gastric banding improves cardio-metabolic risk factors in both metabolically healthy and insulin resistant obese individuals.
Supporting Evidence
- Six months after LAGB, body weight, BMI, and waist circumference were significantly reduced in both MHO and IRO subjects.
- Fasting glucose and insulin levels, triglycerides, AST, and ALT were significantly reduced in both groups.
- Insulin sensitivity increased in both MHO and IRO groups after weight loss.
Takeaway
Losing weight can help people who are obese feel better and be healthier, even if they don't have diabetes or other health problems.
Methodology
The study analyzed the effects of weight loss from laparoscopic adjustable gastric banding on cardio-metabolic risk factors in 190 morbidly obese non-diabetic subjects over 6 months.
Potential Biases
Results may not be generalizable to non-Caucasian populations.
Limitations
Biochemical variables were measured only once, and the study only included Caucasian individuals.
Participant Demographics
190 morbidly obese non-diabetic Caucasian subjects.
Statistical Information
P-Value
P<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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