CYP19 Gene and Breast Cancer Risk in Nigerian Women
Author Information
Author(s): Okobia Michael N, Bunker Clareann H, Zmuda Joseph M, Ezeome Emmanuel R, Anyanwu Stanley NC, Uche Emmanuel EO, Ojukwu Joseph, Kuller Lewis H, Ferrell Robert E
Primary Institution: University of Pittsburgh
Hypothesis
The study evaluates the role of a simple tandem repeat polymorphism in the CYP19 gene in breast cancer susceptibility in Nigerian women.
Conclusion
Harboring 10 or more repeats of the microsatellite (TTTA)n repeats of the CYP19 gene is associated with a modest increased risk of breast cancer in Nigerian women.
Supporting Evidence
- Harboring at least one high risk allele was associated with a 29% increased risk of breast cancer.
- Premenopausal women with high risk alleles had a 35% increased risk of breast cancer.
- Postmenopausal women with high risk alleles had a 27% increased risk of breast cancer.
Takeaway
This study found that women with certain genetic variations in a specific gene may have a higher chance of getting breast cancer.
Methodology
A case-control study with 250 women with breast cancer and 250 controls, using PCR for genotyping.
Limitations
The association was not statistically significant, possibly due to the small number of cases with homozygous genotypes.
Participant Demographics
Nigerian women, both premenopausal and postmenopausal.
Statistical Information
Confidence Interval
95% CI 0.83–2.00
Digital Object Identifier (DOI)
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