Targeting Perineural Invasion in Pancreatic Cancer
2024
Targeting Perineural Invasion in Pancreatic Cancer
publication
Evidence: high
Author Information
Author(s): Garajová Ingrid, Giovannetti Elisa
Primary Institution: University Hospital of Parma, Italy
Hypothesis
Exploring the potential synergistic benefits of anti-neurogenic therapies combined with chemotherapy or immunotherapy might inhibit both pancreatic cancer progression and alleviate cancer-related pain.
Conclusion
Peripheral nerves play a crucial role in the pancreatic tumor microenvironment, influencing cancer progression and pain.
Supporting Evidence
- Neural invasion is present in almost all pancreatic cancers and is linked to worse outcomes.
- Exploring nerve-targeting therapies could help inhibit cancer progression and alleviate pain.
- NGF and its receptor TrkA are overexpressed in pancreatic cancer and correlate with pain severity.
Takeaway
Pancreatic cancer often spreads along nerves, causing pain and making treatment harder. Researchers are looking at ways to target these nerves to help fight the cancer and reduce pain.
Digital Object Identifier (DOI)
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