Anticholinesterase Activity and Bioactive Compound Profiling of Six Hop Varieties
Author Information
Author(s): Sagan Bartłomiej, Czerny Bogusław, Stasiłowicz-Krzemień Anna, Szulc Piotr, Skomra Urszula, Karpiński Tomasz M., Lisiecka Jolanta, Kamiński Adam, Kryszak Aleksandra, Zimak-Krótkopad Oskar, Cielecka-Piontek Judyta
Primary Institution: Pomeranian Medical University
Hypothesis
This study investigates the chemical composition and biological activities of extracts from six hop varieties.
Conclusion
The Aurora variety of hops exhibited the highest antioxidant capacity and effective enzyme inhibition, suggesting its potential for pharmaceutical applications.
Supporting Evidence
- Aurora showed the highest xanthohumol concentration at 0.665 mg/g.
- Zwiegniowski had the highest lupulone content at 9.228 mg/g.
- Aurora exhibited the highest total phenolic content at 22.47 mg GAE/g.
- Aurora and Oregon Fuggle displayed the most potent antioxidant activities.
- Aurora demonstrated significant inhibition of AChE and BChE with IC50 values of 24.39 mg/mL and 20.38 mg/mL, respectively.
- Apolon showed the strongest metal ion binding capacity with an IC50 of 1.04 mg/mL.
- Aurora exhibited the most effective hyaluronidase inhibition with an IC50 of 10.27 mg/mL.
- The study highlights the influence of genetic and environmental factors on the bioactive compound profiles of hop varieties.
Takeaway
Different types of hops can help with health because they have special ingredients that can fight bad stuff in our bodies, and one type, Aurora, is especially good at it.
Methodology
The study used High-Performance Liquid Chromatography (HPLC) and Total Phenolic Content (TPC) analysis to evaluate the chemical composition and biological activities of hop extracts.
Limitations
Further studies are needed to fully understand the potential interactions between hop cone components.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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