Increasing Resistance in Commensal E. coli in Bolivia and Peru
Author Information
Author(s): Bartoloni Alessandro, Pallecchi Lucia, Fiorelli Costanza, Di Maggio Tiziana, Fernandez Connie, Villagran Ana Liz, Mantella Antonia, Bartalesi Filippo, Strohmeyer Marianne, Bechini Angela, Gamboa Herlan, Rodriguez Hugo, Kristiansson Charlotte, Kronvall Göran, Gotuzzo Eduardo, Paradisi Franco, Rossolini Gian Maria
Primary Institution: Università di Firenze
Hypothesis
What is the evolution of antimicrobial-drug resistance in commensal E. coli among children in Bolivia and Peru?
Conclusion
The study found a significant increase in resistance rates to fluoroquinolones and expanded-spectrum cephalosporins among E. coli in children from Bolivia and Peru between 2002 and 2005.
Supporting Evidence
- The study confirmed high resistance rates for ampicillin, trimethoprim-sulfamethoxazole, tetracycline, streptomycin, and chloramphenicol.
- Resistance rates to fluoroquinolones and expanded-spectrum cephalosporins increased significantly from 2002 to 2005.
- Molecular analysis indicated that the increase in resistance to cephalosporins was due to CTX-M-type extended-spectrum β-lactamase determinants.
Takeaway
The study shows that more kids in Bolivia and Peru are getting sick from germs that don't respond to medicine, which is a big problem for health.
Methodology
A cross-sectional study was conducted comparing antimicrobial-drug resistance rates in 2002 and 2005 among healthy children aged 6–72 months in four urban areas.
Limitations
The study did not specifically address factors potentially involved in the increased resistance rates.
Participant Demographics
Healthy children aged 6–72 months from urban areas in Bolivia and Peru.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website