IL-1 and IL-4 as reciprocal regulators of IL-2 induced lymphocyte cytotoxicity
1990
IL-1 and IL-4 as regulators of lymphocyte activity
publication
Evidence: moderate
Author Information
Author(s): N. Ebina, D. Gallardo, H. Shau, S.H. Golub
Primary Institution: UCLA School of Medicine
Hypothesis
Can IL-1 reverse the suppressive effect of IL-4 on IL-2 induced LAK cell development?
Conclusion
IL-4 suppresses IL-2 induced LAK cell development, while IL-1 can reverse this suppression.
Supporting Evidence
- IL-4 suppresses LAK cell development from PBMC.
- IL-1 can reverse the suppression caused by IL-4.
- IL-4 needs to be present at the start of the culture to suppress LAK induction.
- IL-1 enhances IL-2 induced LAK development.
Takeaway
IL-4 can stop certain immune cells from working, but IL-1 can help them work again.
Methodology
Human peripheral blood mononuclear cells were cultured with IL-2 and IL-4, and their cytotoxicity was measured against a melanoma cell line.
Participant Demographics
Healthy volunteers provided the PBMC.
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