Ethyl 8-amino-6-bromoimidazo[1,2-a]pyridine-2-carboxylate
2011
Synthesis of a New Imidazo[1,2-a]pyridine Compound
publication
Evidence: moderate
Author Information
Author(s): Dahmani Siham, Kandri Rodi Youssef, Luis Santiago V., Essassi El Mokhtar, El Ammari Lahcen
Primary Institution: Université Sidi Mohamed Ben Abdallah, Faculté des Sciences et Techniques, Fès, Morocco
Hypothesis
The study investigates a novel method for synthesizing 6-bromo-8-amino-imidazo[1,2-a]pyridine.
Conclusion
The synthesis method yielded the target compound in 65% yield.
Supporting Evidence
- The synthesis method resulted in a 65% yield of the target compound.
- Two independent molecules were found in the asymmetric unit of the compound.
- The fused ring systems in both molecules are nearly planar.
- The study utilized Bruker APEXII CCD diffractometer for data collection.
Takeaway
The researchers found a new way to make a special chemical that could help in medicine.
Methodology
The compound was synthesized by treating ethyl bromopyruvate with 5-bromo-2,3-diaminopyridine in the presence of NaHCO3 in ethanol at reflux.
Digital Object Identifier (DOI)
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