Haplotype Variation of hMYH and Colorectal Cancer Risk in Chinese
Author Information
Author(s): Chen Huimei, Xu Lizhi, Qi Qiufeng, Yao Yanweng, Zhu Ming, Wang Yaping
Primary Institution: Nanjing University
Hypothesis
The haplotype T/A variation of hMYH is related to colorectal carcinogenesis in Chinese.
Conclusion
The haplotype variant allele of hMYH may increase susceptibility to colorectal cancer in the Chinese population.
Supporting Evidence
- The frequency of the haplotype variant allele was statistically higher in CRC patients than in controls.
- The heterozygous frequencies of the hMYH mutation were detected at 4.35% in CRC group and 0.87% in control.
- Immunofluorescence analysis showed that hMYH protein with haplotype T/A variation presented in both nucleus and mitochondria.
Takeaway
Some people have a change in a gene that might make them more likely to get colon cancer. This study looked at that change in Chinese people.
Methodology
A case-control study with 138 colorectal cancer patients and 343 healthy controls was conducted, analyzing genetic variations and protein localization.
Potential Biases
Selection bias could not be excluded due to the low frequency of the variant allele.
Limitations
The study had a limited sample size and did not investigate the glycosylase activity of the mutants in mitochondria.
Participant Demographics
138 Chinese patients with sporadic colorectal cancer and 343 healthy controls.
Statistical Information
P-Value
0.02
Confidence Interval
1.26 – 20.4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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