Chromosome Changes and E-cadherin Mutations in Lobular Breast Cancer
Author Information
Author(s): Huiping C, Sigurgeirsdottir J R, Jonasson J G, Eiriksdottir G, Johannsdottir J T, Egilsson V, Ingvarsson S
Primary Institution: Department of Pathology, National University Hospital, Reykjavik, Iceland
Hypothesis
The study investigates the frequency of loss of heterozygosity (LOH) and mutations in the E-cadherin gene in human lobular breast cancer.
Conclusion
The study found that LOH at 16q is the most frequent chromosome alteration and that E-cadherin acts as a typical tumor suppressor gene in lobular breast cancer.
Supporting Evidence
- 100% of the lobular breast cancer samples showed loss of heterozygosity at 16q21–q22.1.
- A significant association was found between LOH at 16q and lobular histological type.
- Six different somatic mutations in the E-cadherin gene were detected, including insertions and deletions.
- A significant association was found between LOH at 13q and E-cadherin gene mutations.
Takeaway
Researchers looked at breast cancer samples and found that a specific gene often has changes that can lead to cancer.
Methodology
The study analyzed human lobular breast cancer samples for LOH and mutations in the E-cadherin gene.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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