LncRNAs as Biomarkers for Gestational Diabetes
Author Information
Author(s): Stevanović Jovana, Petrović Uroš, Penezić Ana, Radojičić Ognjen, Ardalić Daniela, Mandić Milica, Mandić-Marković Vesna, Miković Željko, Brkušanin Miloš, Nedić Olgica, Dobrijević Zorana
Primary Institution: Institute for the Application of Nuclear Energy, University of Belgrade, Serbia
Hypothesis
The study aims to evaluate the diagnostic potential and prognostic significance of lncRNAs H19, MALAT1, and MEG3 in gestational diabetes mellitus (GDM).
Conclusion
The study suggests that H19 and MALAT1 may serve as diagnostic biomarkers for GDM, showing significant correlations with redox status parameters.
Supporting Evidence
- MALAT1 and H19 were significantly downregulated in GDM patients.
- A correlation was observed between H19 expression and zinc levels in both GDM patients and controls.
- MALAT1 expression positively correlated with NFE2L2 levels in GDM patients.
- H19 exhibited a positive correlation with GR activity in controls.
- H19 expression negatively correlated with SOD activity.
Takeaway
This study looks at special molecules in the blood that might help doctors find out if pregnant women have diabetes. They found that two of these molecules are lower in women with diabetes.
Methodology
The expression levels of lncRNAs were measured in peripheral blood mononuclear cells from 50 GDM patients and 50 healthy controls using qPCR.
Potential Biases
Potential biases may arise from the small sample size and the specific recruitment methods used.
Limitations
The study has a small sample size and a candidate-based approach, limiting the analysis to a limited set of lncRNAs.
Participant Demographics
50 GDM patients and 50 healthy normoglycemic pregnant women, with no significant differences in age or gestational age.
Statistical Information
P-Value
p = 0.0095 for H19, p = 0.012 for MALAT1, p = 0.026 for NFE2L2
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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