8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor
1999
Effects of 8-Chloro-cAMP on Cancer Cell Growth
publication
Author Information
Author(s): Budillon A, Gennaro E Di, Caraglia M, Barbarulo D, Abbruzzese A, Tagliaferri P
Primary Institution: Istituto Nazionale dei Tumori, Fondazione ‘G Pascale’, Napoli, Italy
Hypothesis
Does 8-Chloro-cAMP inhibit the growth-promoting effects of epidermal growth factor in cancer cells?
Conclusion
8-Chloro-cAMP completely abolishes the growth-promoting activity of epidermal growth factor in cancer cells by inhibiting specific signaling pathways.
Supporting Evidence
- 8-Chloro-cAMP completely abolishes the growth-promoting activity of EGF.
- The inhibition of EGF-induced proliferation is linked to the blockade of MAPK activation.
- EGF-R expression and tyrosine phosphorylation increase when cells are treated with 8-Chloro-cAMP.
Takeaway
This study shows that a special compound called 8-Chloro-cAMP can stop cancer cells from growing by blocking signals that tell them to grow.
Methodology
The effects of 8-Cl-cAMP on EGF signaling were investigated in human epidermoid cancer KB cells.
Digital Object Identifier (DOI)
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