Persistence of Mycoplasma genitalium Following Azithromycin Therapy
Author Information
Author(s): Catriona S. Bradshaw, Marcus Y. Chen, Christopher K. Fairley
Primary Institution: Melbourne Sexual Health Centre, The Alfred Hospital, Melbourne, Victoria, Australia
Hypothesis
To determine clinical outcomes and cure rates for M.genitalium genital infection in men and women following azithromycin 1 g.
Conclusion
Azithromycin 1 g was associated with unacceptable rates of persistent M.genitalium infection, which could be eradicated with moxifloxacin.
Supporting Evidence
- Of 1538 males and 313 females tested, 191 (10%) tested positive for M.genitalium.
- 84% of individuals treated with azithromycin did not have persistence of M.genitalium.
- Moxifloxacin was effective in eradicating persistent infection in all cases not responding to azithromycin.
Takeaway
Doctors gave a medicine called azithromycin to people with a germ called M.genitalium, but it didn't work for everyone, and some needed a different medicine to get better.
Methodology
Patients were tested for M.genitalium and treated with azithromycin, followed by a test-of-cure one month later.
Potential Biases
Risk of reinfection relies on patient report, which may be unreliable.
Limitations
The study was conducted in a specific patient population at an STD clinic, which may not be generalizable to all individuals.
Participant Demographics
1538 males and 313 females were tested.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI: 77–90%
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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