A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion
2011
How Extracellular Hsp90 Affects Glioblastoma Cell Invasion
publication
Evidence: high
Author Information
Author(s): Gopal Udhayakumar, Bohonowych Jessica E., Lema-Tome Carla, Liu Angen, Garrett-Mayer Elizabeth, Wang Bingcheng, Isaacs Jennifer S.
Primary Institution: Medical University of South Carolina
Hypothesis
Does extracellular Hsp90 regulate glioblastoma cell invasion through EphA2 signaling?
Conclusion
Extracellular Hsp90 is crucial for glioblastoma cell invasion by activating EphA2 signaling.
Supporting Evidence
- eHsp90 signaling is essential for sustaining AKT activation and GBM cell motility.
- eHsp90 promotes the recruitment of LRP1 to EphA2 in an AKT dependent manner.
- Hypoxia increases surface expression of eHsp90 and LRP1, enhancing GBM cell invasion.
- Interference with eHsp90 function significantly inhibits GBM cell motility and invasion.
Takeaway
This study shows that a protein called extracellular Hsp90 helps brain cancer cells move and invade by working with another protein called EphA2.
Methodology
The study used biochemical assays, cell motility, and invasion assays to investigate the role of eHsp90 in glioblastoma.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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