Outcomes of Hydronephrosis Related to Retroperitoneal Fibrosis
Author Information
Author(s): Liu Hongyan, Gao Hui, Zhao Jin-xia, Wong Ut-kei, Liu Shi-bo, Liu Jian, Zhang Ge, Wang Kuan-ting, Wang Yan, Zhao Lin, Ma Xiang-bo, Lu Yue-wu, Zhang Xue-wu
Primary Institution: Peking University International Hospital
Hypothesis
What are the risk factors for poor prognosis in patients with hydronephrosis caused by retroperitoneal fibrosis?
Conclusion
Severity of kidney dysfunction and inflammation status were related to the poor prognosis of hydronephrosis induced by retroperitoneal fibrosis.
Supporting Evidence
- Renal impairment was observed in 88.35% of the patients.
- 36 patients had poor prognosis after 60.43 months of follow-up.
- Glucocorticoid-based therapy could reduce the need for long-term ureteral stenting.
Takeaway
This study looked at patients with a rare disease that can cause kidney problems. It found that how bad the kidney damage is can help predict how well patients will do.
Methodology
A multi-center retrospective cohort study analyzing 115 patients diagnosed with retroperitoneal fibrosis-related hydronephrosis from 9 clinical centers in China.
Potential Biases
Potential biases due to the retrospective nature of the study and incomplete data from the surgery department.
Limitations
The study is retrospective, and laboratory tests and imaging were not thoroughly assessed.
Participant Demographics
Mean age was 58.83 years, with 69.57% being men.
Statistical Information
P-Value
0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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