Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation
2025
Effects of Nrf2 on Skin Inflammation
publication
Author Information
Author(s): Michael Koch, L. Ferrarese, M. Ben-Yehuda Greenwald, S. Werner
Primary Institution: ETH Zürich
Hypothesis
How does the alteration of Nrf2 activity contribute to the pathophysiology of atopic dermatitis?
Conclusion
Limited activation of Nrf2 may protect the skin and improve barrier function in atopic dermatitis patients.
Supporting Evidence
- Decreased Nrf2 activity contributes to DNA damage and senescence in the epidermis.
- Limited pharmacological activation of Nrf2 can partially rescue barrier defects in atopic dermatitis.
- Extended Nrf2 activation can have detrimental effects and should be avoided.
Takeaway
Nrf2 helps keep our skin healthy, but if it's not working right, it can lead to skin problems. We found that just the right amount of Nrf2 can help protect the skin.
Methodology
We used mice lacking fibroblast growth factor receptors in keratinocytes to study Nrf2's role in atopic dermatitis.
Digital Object Identifier (DOI)
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