Role of SNX16 in the Dynamics of Tubulo-Cisternal Membrane Domains of Late Endosomes
2011
Role of SNX16 in Late Endosome Dynamics
publication
Evidence: moderate
Author Information
Author(s): Brankatschk Ben, Pons Véronique, Parton Robert G., Gruenberg Jean
Primary Institution: Department of Biochemistry, University of Geneva, Geneva, Switzerland
Hypothesis
How does SNX16 influence the dynamics of late endosomal membranes?
Conclusion
SNX16 is involved in the regulation of late endosome membrane dynamics and cholesterol transport.
Supporting Evidence
- SNX16 is selectively enriched on tubulo-cisternal elements of late endosomes.
- SNX16 is involved in tubule formation and cholesterol transport.
- Excess SNX16 interferes with late endosomal dynamics and trafficking.
Takeaway
SNX16 helps control how late endosomes move and work, which is important for transporting cholesterol in cells.
Methodology
The study involved transfecting cells with SNX16 constructs and analyzing their distribution using fluorescence microscopy.
Limitations
The study did not conclusively investigate the effects of SNX16 depletion.
Digital Object Identifier (DOI)
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