Neuroregeneration in Neurodegenerative Disorders
Author Information
Author(s): Enciu Ana M, Nicolescu Mihnea I, Manole Catalin G, Mureşanu Dafin F, Popescu Laurenţiu M, Popescu Bogdan O
Hypothesis
The brain possesses, at least in early and medium stages of disease, a 'neuroregenerative reserve' that could be exploited by growth factors or stem cells-neurorestoration therapies.
Conclusion
There is evidence of impaired neuroregeneration resources in Alzheimer's Disease and Parkinson's Disease, but proper stimulation or supply of growth factors may restore some cognitive loss and improve behavioral skills.
Supporting Evidence
- Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease.
- Neuroplasticity is a compensatory measure for neuronal loss in Alzheimer's Disease.
- Growth factors like BDNF and NGF are crucial for neuronal survival and function.
Takeaway
The brain can heal itself a little, especially in the early stages of diseases like Alzheimer's and Parkinson's, if we help it with special treatments.
Methodology
The paper reviews current data regarding neuroregeneration in Alzheimer's Disease and Parkinson's Disease.
Limitations
The study discusses various contradictory results in literature regarding neurogenesis and neuroplasticity in neurodegenerative diseases.
Digital Object Identifier (DOI)
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