Plasma Proteome Profiles Linked to Inflammation, Angiogenesis, and Cancer
Author Information
Author(s): Kelly-Spratt Karen S., Pitteri Sharon J., Gurley Kay E., Liggitt Denny, Chin Alice, Kennedy Jacob, Wong Chee-Hong, Zhang Qing, Buson Tina Busald, Wang Hong, Hanash Samir M., Kemp Christopher J.
Primary Institution: Fred Hutchinson Cancer Research Center
Hypothesis
Can plasma protein changes in mouse models of inflammation and angiogenesis be distinguished from those in cancer models?
Conclusion
The study identifies distinct plasma protein profiles associated with cancer compared to non-cancerous inflammatory conditions.
Supporting Evidence
- Approximately one third of all quantified plasma proteins exhibited a significant change in abundance compared to control mice.
- The majority of altered proteins were unique to each model.
- Proteins involved in inflammation and angiogenesis were identified as significantly altered in the plasma of cancer-bearing mice.
- Distinct plasma protein profiles can help differentiate between cancer and non-cancerous conditions.
Takeaway
Researchers looked at blood proteins in mice to see how they change with inflammation and cancer, finding that some proteins are unique to cancer.
Methodology
The study used mouse models of inflammation and cancer to analyze plasma protein changes through mass spectrometry.
Potential Biases
Potential bias from the choice of mouse models and the methods of protein quantification.
Limitations
The study is limited to mouse models, which may not fully represent human conditions.
Participant Demographics
Female FVB mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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