Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors
1999
Substance P and Tumor Growth in Glioma Cells
publication
Evidence: moderate
Author Information
Author(s): Palma C, Nardelli F, Manzini S, Maggi C A
Primary Institution: Menarini Ricerche
Hypothesis
Substance P activates responses correlated with tumor growth in human glioma cell lines bearing tachykinin NK1 receptors.
Conclusion
Substance P stimulates tumor growth in certain glioma cell lines by activating specific receptors.
Supporting Evidence
- Substance P was shown to increase IL-6 secretion in glioma cell lines with NK1 receptors.
- The presence of tachykinin NK1 receptors was confirmed in specific glioma cell lines.
- Substance P enhanced DNA synthesis and proliferation in NK1R+ glioma cells.
Takeaway
Substance P is like a signal that makes some brain cancer cells grow faster, but there are ways to block that signal.
Methodology
The study involved radioligand binding studies and assessments of cytokine secretion and cell proliferation in glioma cell lines.
Digital Object Identifier (DOI)
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