Modulation of COUP-TF Expression in a Cnidarian by Ectopic Wnt Signalling and Allorecognition
2011
COUP-TF Expression in Hydractinia and Its Role in Allorecognition
publication
Evidence: moderate
Author Information
Author(s): Duffy David J., Frank Uri
Primary Institution: National University of Ireland Galway
Hypothesis
How does COUP-TF expression relate to neuronal differentiation and allorecognition in Hydractinia echinata?
Conclusion
COUP-TF is likely involved in neuronal and nematocyte differentiation, particularly during allorecognition events.
Supporting Evidence
- COUP-TF expression was first detected in post-gastrula stages and was upregulated during allorecognition.
- Global activation of Wnt signaling resulted in increased COUP-TF expression.
- COUP-TF was transiently upregulated during self-stolon encounters but downregulated after self-recognition.
Takeaway
This study shows that a gene called COUP-TF helps certain sea creatures called Hydractinia recognize and react to their neighbors, which is important for their survival.
Methodology
The researchers cloned a COUP-TF homologue and analyzed its expression during development and allorecognition using in situ hybridization and quantitative PCR.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website