sST2 and IL-33 in Pregnancy and Pre-Eclampsia
Author Information
Author(s): Granne Ingrid, Southcombe Jennifer H., Snider James V., Tannetta Dionne S., Child Tim, Redman Christopher W. G., Sargent Ian L.
Primary Institution: University of Oxford
Hypothesis
The study investigates the role of sST2 and IL-33 in normal pregnancy and pre-eclampsia.
Conclusion
sST2 levels increase in the third trimester of normal pregnancy and are significantly elevated in pre-eclampsia, potentially serving as a biomarker for the disease.
Supporting Evidence
- sST2 levels were significantly increased in women with pre-eclampsia compared to normal pregnant and non-pregnant women.
- Circulating sST2 was found to be elevated in the third trimester of normal pregnancy.
- IL-33 levels did not show significant variation between normal and pre-eclamptic pregnancies.
Takeaway
This study found that a substance called sST2 goes up in pregnant women, especially those who might get a condition called pre-eclampsia, which can be harmful to both mom and baby.
Methodology
Blood samples were taken from women with pre-eclampsia and matched normal pregnant women to measure levels of sST2 and IL-33.
Potential Biases
Potential bias in participant selection and matching criteria.
Limitations
The study may not account for all variables affecting sST2 levels, and the sample size, while significant, may not represent all populations.
Participant Demographics
Women with pre-eclampsia and matched normal pregnant women, aged 20-40.
Statistical Information
P-Value
p<0.001
Confidence Interval
0.642 to 0.984
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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