Tenidap: A New Anti-Inflammatory Drug for Rheumatoid Arthritis
Author Information
Author(s): C. S. Lau, J. J. F. Belch
Primary Institution: University Department of Medicine, Ninewells Hospital and Medical School
Hypothesis
Does tenidap have free radical scavenging effects that could be beneficial in treating rheumatoid arthritis?
Conclusion
Tenidap has general free radical scavenging effects that may be clinically relevant in the treatment of rheumatoid arthritis.
Supporting Evidence
- Tenidap has been shown to modify white blood cell behavior.
- Tenidap has dual inhibitory activity against cyclo-oxygenase and 5-lipoxygenase.
- The study shows that tenidap has general free radical scavenging effects.
- The scavenging activity of tenidap is dose-dependent at concentrations above 20 µg/ml.
- Tenidap's therapeutic range in serum is between 15 and 30 µg/ml.
Takeaway
Tenidap is a new medicine that helps reduce inflammation in arthritis by cleaning up harmful particles in the body.
Methodology
An in vitro assay was used to assess the free radical scavenging activity of tenidap at various concentrations.
Limitations
The study does not demonstrate which part of tenidap is responsible for its free radical scavenging effect.
Statistical Information
P-Value
<0.005
Statistical Significance
p<0.005
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