Celecoxib and DMC Reduce Survivin and Induce Cancer Cell Death
Author Information
Author(s): Pyrko Peter, Soriano Nathaniel, Kardosh Adel, Liu Yen-Ting, Uddin Jasim, Petasis Nicos A, Hofman Florence M, Chen Ching-Shih, Chen Thomas C, Schönthal Axel H
Primary Institution: University of Southern California
Hypothesis
Can celecoxib and its analog DMC down-regulate survivin expression and induce apoptosis in tumor cells?
Conclusion
Celecoxib and DMC can effectively down-regulate survivin and induce apoptosis in tumor cells, suggesting their potential as anti-cancer agents.
Supporting Evidence
- Both celecoxib and DMC down-regulate survivin in various tumor cell lines.
- The down-regulation of survivin correlates with increased apoptosis.
- Survivin down-regulation occurs independently of COX-2 inhibition.
- DMC enhances the cytotoxic effects of irinotecan in glioblastoma cells.
- Both drugs show similar effects in vivo, reducing tumor growth in mouse models.
Takeaway
Celecoxib and a similar drug called DMC can help kill cancer cells by lowering a protein that helps them survive.
Methodology
The study involved treating various tumor cell lines with celecoxib and DMC, measuring survivin levels and apoptosis through Western blot analysis and TUNEL assays.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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