Tim1 and Tim3 are not essential for experimental allergic asthma
2011
Tim1 and Tim3 are not essential for experimental allergic asthma
Sample size: 10
publication
10 minutes
Evidence: moderate
Author Information
Author(s): J L Barlow, S H Wong, S J Ballantyne, H E Jolin, A N J McKenzie
Primary Institution: MRC Laboratory of Molecular Biology
Hypothesis
Are Tim1 and Tim3 important in regulating antigen-driven lung allergy and inflammation?
Conclusion
Tim1 and Tim3 are not essential for the induction of the type-2 response in lung allergy.
Supporting Evidence
- Tim1-deficient mice showed a small but significant decrease in cell infiltration in the lung and blood eosinophilia.
- Tim3 was expressed on CD4+ T cells in the allergic lung.
- Tim1 expression was restricted to CD86+ B cells.
Takeaway
The study found that two proteins, Tim1 and Tim3, are not needed for asthma-like reactions in mice, even though they were thought to be important.
Methodology
The study used Tim1- and Tim3-deficient mice to assess allergic lung inflammation.
Limitations
The study primarily focused on mouse models, which may not fully represent human asthma.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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