A stochastic simulation model to determine the sample size of repeated national surveys to document freedom from bovine herpesvirus 1 (BoHV-1) infection
2007

Model for Estimating Sample Size in Cattle Disease Surveys

Sample size: 1000 publication 10 minutes Evidence: high

Author Information

Author(s): Lea Knopf, Heinzpeter Schwermer, Katharina D. C. Stärk

Primary Institution: Swiss Federal Veterinary Office

Hypothesis

Can a stochastic model improve the estimation of sample sizes for national surveys to document freedom from bovine herpesvirus 1 (BoHV-1) infection?

Conclusion

The model accurately estimated the pre-survey probability of freedom from infection and serves as a flexible tool for adapting to changing conditions in livestock health.

Supporting Evidence

  • The model highlighted the importance of undetected domestic infection spread.
  • Sensitivity analysis showed strong correlation between pre-survey prevalence and domestic herd infection rates.
  • The model can be adapted for various infectious agents beyond BoHV-1.

Takeaway

This study created a computer model to help figure out how many cattle need to be tested to make sure they are healthy and free from a specific virus.

Methodology

The model used Monte Carlo simulations to calculate the pre-survey probability of freedom from infection based on various infection pathways and parameters.

Potential Biases

Potential biases may arise from assumptions about detection probabilities and the representativeness of previous survey results.

Limitations

The model did not account for clustered outbreaks or detailed data on transport conditions for imported animals.

Participant Demographics

The study focused on cattle herds in Switzerland, with a population size of approximately 50,000 herds.

Statistical Information

P-Value

0.011

Confidence Interval

95% CI 96.63–97.31%

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1746-6148-3-10

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