To Live or to Die: Prosurvival Activity of PPARγ in Cancers
2008
The Role of PPARγ in Cancer: A Review
publication
Evidence: moderate
Author Information
Author(s): Y. Lynn Wang, Q. Miao
Primary Institution: Weill Cornell Medical College
Hypothesis
Does PPARγ promote tumor survival and progression in various cancers?
Conclusion
PPARγ is overexpressed in many cancers and may contribute to tumor survival under adverse conditions.
Supporting Evidence
- PPARγ is overexpressed in various cancers, including prostate and pancreatic cancer.
- High levels of PPARγ expression correlate with poor patient survival in pancreatic cancer.
- PPARγ may enhance tumor cell survival under nutrient-deprived conditions.
Takeaway
PPARγ is a protein that helps cancer cells survive, especially when they don't have enough food or oxygen.
Methodology
The article reviews literature from the past decade on PPARγ's role in cancer, focusing on expression levels, animal models, and clinical trials.
Limitations
The review is based on existing literature and may not cover all studies or perspectives on PPARγ.
Digital Object Identifier (DOI)
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