Using Pig Eyes to Study Drug Delivery in Human Eyes
Author Information
Author(s): Nicoli S., Ferrari G., Quarta M., Macaluso C., Govoni P., Dallatana D., Santi P.
Primary Institution: University of Parma, Italy
Hypothesis
Can porcine sclera serve as a reliable model for human sclera in drug delivery studies?
Conclusion
Porcine sclera is a good model for human sclera in drug delivery experiments, especially when considering tissue thickness.
Supporting Evidence
- Porcine sclera is approximately twofold thicker than human sclera.
- Both human and porcine scleras have similar histology and collagen organization.
- Human sclera is two to threefold more permeable than porcine sclera for the tested molecules.
Takeaway
Scientists found that pig eyes can help us understand how drugs move through human eyes, which is important for treating eye diseases.
Methodology
The study compared the thickness, water content, and permeability of human and porcine scleras using various model molecules.
Limitations
The study primarily focused on in vitro conditions, which may not fully replicate in vivo scenarios.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
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