Platelet Indicators in Type 2 Diabetes Patients with Liver Disease
Author Information
Author(s): Onișor Danusia, Roiban Andrada Larisa, Cernea Simona, Abenavoli Ludovico
Primary Institution: George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureş
Hypothesis
This study aimed to investigate the platelet hematometric indices in patients with T2DM and MASLD.
Conclusion
Male patients with T2DM and MASLD had lower platelet count and PTC and larger PDW, with higher insulin resistance associated with these changes.
Supporting Evidence
- Patients with lower platelet counts had higher fatty liver index and insulin resistance.
- Platelet count correlated negatively with liver function tests and insulin resistance.
- Male patients had a higher percentage in the lower platelet count group.
Takeaway
This study looked at how platelets behave in people with diabetes and liver disease, finding that men had fewer platelets and more variability in their size.
Methodology
Demographic and medical data were collected from 271 participants, and blood samples were analyzed for various parameters.
Potential Biases
Potential biases due to the observational nature of the study and reliance on non-invasive diagnostic methods.
Limitations
The study was cross-sectional, relied on ultrasound for liver steatosis diagnosis, and had a small number of patients with extreme platelet counts.
Participant Demographics
271 participants (149 females and 122 males) with a mean age of 65.0 years.
Statistical Information
P-Value
p = 0.0088 for FLI comparison, p = 0.0008 for HOMA-IR comparison, p < 0.0001 for platelet count comparison.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website