Effect of individualized versus conventional perioperative blood pressure management on postoperative major complications in high-risk patients undergoing noncardiac surgery: study protocol for the SPROUT-4 multicenter randomized controlled trial
2024

Blood Pressure Management in Surgery

Sample size: 1896 publication Evidence: moderate

Author Information

Author(s): Chung Jaeyeon, Koo Chang-Hoon, Park Jungchan, Kim Hye-Bin, Bae Jinyoung, Ju Jae-Woo, Lee Soowon, Oh Ah Ran, Kim Hyo Sung, Park Soo Jung, Jeon Yunseok, Nam Karam

Primary Institution: Seoul National University Hospital

Hypothesis

Does individualized perioperative blood pressure management decrease the incidence of postoperative major adverse outcomes compared to conventional management?

Conclusion

The study aims to determine if individualized blood pressure management reduces major complications in high-risk patients undergoing noncardiac surgery.

Supporting Evidence

  • Intraoperative hypotension occurs in nearly 70% of noncardiac surgeries.
  • Current blood pressure management strategies are based on unproven universal thresholds.
  • Individualized management may reduce postoperative complications based on previous studies.

Takeaway

This study is trying to find out if adjusting blood pressure based on each patient's needs during surgery can help them recover better than just following standard rules.

Methodology

This is a multicenter, randomized controlled trial enrolling high-risk patients undergoing major noncardiac surgery, comparing individualized blood pressure management to conventional management.

Potential Biases

Potential bias due to the nature of the interventions being known to anesthesiologists.

Limitations

The study may not capture long-term complications beyond 7 days post-surgery.

Participant Demographics

High-risk patients aged ≥65 years or ≥45 years with specific comorbidities.

Statistical Information

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/s13063-024-08707-4

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