Oxygenation Effect of Interventional Lung Assist in Acute Lung Injury
Author Information
Author(s): Zick Günther, Frerichs Inéz, Schädler Dirk, Schmitz Gunnar, Pulletz Sven, Cavus Erol, Wachtler Felix, Scholz Jens, Weiler Norbert
Primary Institution: Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany
Hypothesis
A pumpless arteriovenous extracorporeal membrane oxygenator (interventional lung assist (ILA)) does not significantly improve oxygenation in a lavage model of acute lung injury.
Conclusion
Oxygenation is increased by ILA in severe lung injury, but the effect is small and may not justify its use if oxygenation is the primary therapy goal.
Supporting Evidence
- ILA significantly increased the arterial partial pressure of O2 from 64 Torr to 71 Torr and 74 Torr with blood flow through one and both femoral arteries, respectively.
- O2 delivery through ILA increased with extracorporeal shunt flow.
- Pulmonary artery pressures were significantly reduced when ILA was in operation.
Takeaway
The study tested a device that helps get oxygen into the blood of pigs with lung injury, and it found that while it helps a little, it might not be worth using just for that.
Methodology
The study was a prospective experimental study conducted on seven pigs with induced acute lung injury using bronchoalveolar lavage.
Limitations
The study was conducted on pigs, which may not fully represent human responses, and the improvement in oxygenation was small.
Participant Demographics
Seven domestic pigs (Deutsches Landschwein) with a body weight of 48–60 kg.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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