The Protein Kinase Tor1 Regulates Adhesin Gene Expression in Candida albicans
2009
The Role of Tor1 in Regulating Adhesin Gene Expression in Candida albicans
publication
10 minutes
Evidence: high
Author Information
Author(s): Bastidas Robert J., Heitman Joseph, Cardenas Maria E.
Primary Institution: Duke University Medical Center
Hypothesis
Tor1 signaling regulates the expression of adhesin genes in Candida albicans.
Conclusion
Tor1 negatively controls cellular adhesion by regulating the expression of adhesin genes.
Supporting Evidence
- Tor1 signaling is conserved from yeasts to humans.
- Rapamycin treatment induced extensive cellular aggregation in an adhesin-dependent manner.
- Tor1 regulates the expression of several cell wall and hyphal specific genes.
Takeaway
This study shows that a protein called Tor1 helps control how Candida albicans sticks to surfaces by managing the genes that make sticky proteins.
Methodology
The study used global transcriptional profiling and genetic manipulation to analyze the role of Tor1 in gene expression related to adhesion.
Limitations
The study did not explore the effects of Tor1 in all possible environmental conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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