OpenADAM: A System for Managing Genotype Data
Author Information
Author(s): Yeung J MY, Sham P C, Chan A SW, Cherny S S
Primary Institution: The University of Hong Kong
Conclusion
OpenADAM provides an open source database system for management of Affymetrix genome-wide association SNP data.
Supporting Evidence
- OpenADAM allows users to manage genotype data remotely through a web interface.
- The system supports various algorithms for genotype calling and data export.
- A novel method for estimating genotyping error rates is implemented.
Takeaway
OpenADAM is a tool that helps researchers organize and analyze genetic data from studies about diseases. It makes it easier to work with a lot of information from DNA tests.
Methodology
The software uses algorithms for genotype calling and stores data in a MySQL database, accessible via a web interface.
Potential Biases
There is a risk of bias in error estimation due to the reliance on linkage disequilibrium information.
Limitations
The method for estimating genotyping error may overestimate errors and requires further validation.
Digital Object Identifier (DOI)
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