Circulating Immune Complexes and Trace Elements as Markers in Oral Precancer and Cancer
Author Information
Author(s): Sunali S Khanna, Freny R Karjodkar
Primary Institution: Nair Hospital Dental College, Mumbai, India
Hypothesis
To evaluate the levels of circulating immune complexes and trace elements in serum of patients with oral precancer and cancer.
Conclusion
The study suggests that immunological and biological markers may be associated with the pathogenesis of oral premalignant and malignant lesions.
Supporting Evidence
- Increased circulating immune complex levels were found in precancer and cancer patients.
- Serum copper levels increased from precancer to cancer patients.
- Serum iron levels decreased significantly in the cancer group.
- Selenium levels showed a marked decrease in the cancer group.
- Age, serum iron, CIC, and serum selenium were identified as best predictors for disease occurrence.
Takeaway
Doctors looked at blood samples from people with mouth cancer and found certain markers that could help spot the disease earlier.
Methodology
The study estimated circulating immune complexes and trace elements in serum using various biochemical methods.
Potential Biases
Potential bias due to the selection of participants from a single institution.
Limitations
The study was limited to a specific population and may not be generalizable.
Participant Demographics
Participants included 30 patients with oral submucous fibrosis, 30 with oral squamous cell carcinoma, and 30 normal subjects, aged 25-70.
Statistical Information
P-Value
1.10E-13
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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