Schizophrenia as Failure of Left Hemispheric Dominance for the Phonological Component of Language Laterality Lack in Psychosis
2009

Schizophrenia and Language Processing

Sample size: 24 publication Evidence: moderate

Author Information

Author(s): Angrilli Alessandro, Spironelli Chiara, Elbert Thomas, Crow Timothy J., Marano Gianfranco, Stegagno Luciano

Primary Institution: Department of General Psychology, University of Padova, Padova, Italy

Hypothesis

The study investigates whether individuals with schizophrenia exhibit a failure of left hemispheric dominance for the phonological component of language.

Conclusion

The study found that individuals with schizophrenia show a specific deficit in left hemispheric dominance during phonological processing, which may explain certain symptoms like auditory hallucinations.

Supporting Evidence

  • Schizophrenic patients were slower to respond than healthy controls.
  • Patients made more errors than controls in language tasks.
  • Phonological tasks showed significant left lateralization in controls but not in patients.

Takeaway

People with schizophrenia have trouble using the left side of their brain for language, which can make them hear voices that aren't there.

Methodology

The study involved 12 schizophrenic patients and 12 matched healthy controls who participated in an event-related potential experiment while performing language tasks.

Potential Biases

Potential bias due to the selection of patients with minimal neuroleptic medication.

Limitations

The study's findings may be limited by the small sample size and the specific demographic characteristics of the participants.

Participant Demographics

12 schizophrenic patients (6 women, mean age 37.9) and 12 matched healthy controls (6 women, mean age 35.8).

Statistical Information

P-Value

p<0.001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0004507

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