Effects of High-Fat Diet on Breast Cancer in Mice
Author Information
Author(s): Dogan Soner, Hu Xin, Zhang Yan, Maihle Nita J, Grande Joseph P, Cleary Margot P
Primary Institution: Hormel Institute, University of Minnesota
Hypothesis
Leptin is a growth factor for breast/mammary cancer cells.
Conclusion
Diet impacts mammary tumor development and leptin signaling proteins independently of body weight.
Supporting Evidence
- Obesity-Prone mice had a higher incidence of palpable mammary tumors compared to Low-Fat mice.
- Serum leptin levels were significantly higher in Obesity-Prone mice.
- Low-Fat mice showed higher expression of pro-apoptotic proteins compared to High-Fat mice.
Takeaway
Mice that ate a high-fat diet got heavier and had more breast tumors than those that ate a low-fat diet.
Methodology
MMTV-TGF-α mice were fed low-fat or high-fat diets from 10 to 85 weeks of age, and tumor development was monitored.
Potential Biases
Potential bias in the classification of obesity-prone and obesity-resistant groups.
Limitations
The study was limited to a specific mouse model and diet duration.
Participant Demographics
Female MMTV-TGF-α mice.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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