Construction of Cisplatin-18-Crown-6 Complexes Through Supramolecular Chemistry to Improve Solubility, Stability, and Antitumor Activity
2024
Improving Cisplatin's Effectiveness with 18-Crown-6
publication
Evidence: high
Author Information
Author(s): Gao Yue, Huang Yeqi, Ren Chuanyu, Xiong Si, Guo Xia, Zhao Ziyu, Guo Ling, Huang Zhengwei, Valente Artur
Primary Institution: Jinan University
Hypothesis
Can 18-crown-6 enhance the solubility, stability, and antitumor activity of cisplatin?
Conclusion
The DDP@18-crown-6 complex significantly improves the solubility and stability of cisplatin, enhancing its anticancer efficacy.
Supporting Evidence
- The DDP@18-crown-6 complex increased the solubility of DDP by a factor of 5.03.
- Stability studies showed that the DDP@18-crown-6 complex maintained 99.08% of DDP concentration after 4 days.
- In vitro assays indicated that the DDP@18-crown-6 complex had an IC50 of 5.043 µg/mL, compared to 8.629 µg/mL for raw DDP.
Takeaway
This study shows that adding 18-crown-6 to cisplatin helps it dissolve better and stay stable, making it work better against cancer.
Methodology
The study used UV-visible spectroscopy, FT-IR, Raman spectroscopy, and molecular docking to analyze the DDP@18-crown-6 complex.
Statistical Information
P-Value
4.035
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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