Pharmacist-Led Management Model and Medication Adherence in Chronic Heart Failure
Author Information
Author(s): Wang Lingjiao MD, Zhao Yuanyuan MD, Han Liping MD, Zhang Huan MD, Chen Hejun MD, Liu Aixia MD, Yu Jing MD, Fu Ran MD, Duan Liguang MD, An Feiyue BS, Guo Zhimin MD, Lun Yang BS, Chen Chaoli BS, Cheng Fangfang BS, Song Chaohui BS, Gao Haixia MD PhD, Zhou Chunhua MD PhD
Primary Institution: The First Hospital of Hebei Medical University, Hebei, China
Hypothesis
Can a pharmacist-led management model improve medication adherence among patients with chronic heart failure (CHF) compared with a conventional management model?
Conclusion
The study found that a pharmacist-led management model is effective for improving medication adherence among patients with CHF.
Supporting Evidence
- Patients in the intervention group showed an 8.1% higher proportion of days covered (PDC) for heart failure medication at 52 weeks.
- 74.8% of participants had severe limitations in physical activity due to heart failure.
- Significant improvements in quality of life were observed in the intervention group compared to the control group.
Takeaway
This study shows that having a pharmacist help patients with heart failure can make them better at taking their medicine.
Methodology
This was a multicenter randomized clinical trial conducted over 52 weeks with patients assigned to either a pharmacist-led management intervention or usual care.
Potential Biases
Some participants in the control group requested to communicate with nurses through the messaging application, which was not accounted for in the analysis.
Limitations
The study's sample may not be representative of the general population in China, and self-reported medication use may introduce variability.
Participant Demographics
Participants had a mean age of 63.2 years, included 59.1% males, and 74.8% had severe heart failure (NYHA class III or IV).
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 5.5%-10.7%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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