A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C
2024
How Different Cell Types Use G Proteins to Control Calcium Levels
publication
Author Information
Author(s): Gao Zhan-Guo, Gao Ray R., Meyer Clayton K., Jacobson Kenneth A.
Hypothesis
The study investigates how G proteins and protein kinase C influence calcium mobilization in different cell types.
Conclusion
The role of G proteins in calcium signaling varies by cell type and receptor, with some cells relying on Gαq/11 while others do not.
Supporting Evidence
- In HEK293 cells, Gαq/11 inhibitors reduced calcium increase from various receptors.
- In T24 bladder cancer cells, G i inhibitors affected calcium increase from A2B adenosine receptors.
- PKC activators influenced calcium mobilization differently depending on the cell type.
Takeaway
Different types of cells use different helpers to manage calcium levels, and sometimes they can do it without one of those helpers.
Digital Object Identifier (DOI)
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