Endosialin in Rectal Cancer and Radiotherapy
Author Information
Author(s): Zhang Zhi-Yong, Zhang Hong, Adell Gunnar, Sun Xiao-Feng
Primary Institution: Linköping University
Hypothesis
Is endosialin expression related to radiotherapy response and clinicopathological variables in rectal cancers?
Conclusion
Endosialin expression may be involved in the progression of rectal cancers, but no direct relationship with radiotherapy responses was found.
Supporting Evidence
- Endosialin expression increased from normal mucosa to tumor.
- In the radiotherapy group, endosialin was associated with Cox-2, p73, and PRL expression.
- Endosialin expression was more frequent in tumors with infiltrative growth patterns.
Takeaway
This study looked at a protein called endosialin in rectal cancer to see if it helps tumors grow or respond to treatment, but it didn't find a clear link to treatment success.
Methodology
Endosialin was examined in normal mucosa and primary tumors using immunohistochemistry.
Limitations
The study had a limited number of patients, which may affect the conclusions.
Participant Demographics
Mean age of patients was 67 years, with a range of 36-85 years.
Statistical Information
P-Value
p < 0.05
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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