The heme oxygenase-1 and c-FLIP in acute myeloid leukemias: two non-redundant but mutually exclusive cellular safeguards protecting cells against TNF-induced cell death?
2010
Heme Oxygenase-1 and c-FLIP in Acute Myeloid Leukemias
publication
Author Information
Author(s): Shirley S., Micheau O.
Primary Institution: INSERM, U866, Dijon, France
Hypothesis
Can heme oxygenase-1 and c-FLIP provide non-redundant cellular safeguards against TNF-induced cell death in acute myeloid leukemia?
Conclusion
Heme oxygenase-1 provides cytoprotection in acute myeloid leukemia cells, independent of NF-κB activation.
Supporting Evidence
- HO-1 can protect AML cells from TNF-induced apoptosis even when NF-κB is inactive.
- c-FLIP negatively regulates HO-1 expression, affecting cell death responses.
- Simultaneous inactivation of c-FLIP and HO-1 increases sensitivity of AML cells to TNF.
Takeaway
This study shows that two proteins, heme oxygenase-1 and c-FLIP, help protect leukemia cells from dying when they are exposed to a harmful signal.
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