HYBRIDdb: a database of hybrid genes in the human genome
2007
HYBRIDdb: A Database of Hybrid Genes in Humans
Sample size: 28171
publication
Evidence: moderate
Author Information
Author(s): Kim Dae-Soo, Huh Jae-Won, Kim Heui-Soo
Primary Institution: Pusan National University
Hypothesis
Hybrid genes may play a role in human evolution and disease.
Conclusion
The HYBRIDdb database will provide genome scientists with insight into potential roles for hybrid genes in human evolution and disease.
Supporting Evidence
- Hybrid genes can be created by various mechanisms such as trans-splicing and genome rearrangement.
- The study identified 2,344 gene pairs as hybrid forms of transcriptional products.
- HYBRIDdb provides a user-friendly interface for exploring hybrid genes.
Takeaway
HYBRIDdb is a tool that helps scientists find and study hybrid genes in humans, which can be important for understanding diseases and evolution.
Methodology
The database was created by analyzing mRNA, EST, cDNA, and genomic DNA sequences to identify hybrid genes among 28,171 genes.
Limitations
The study relies on publicly available transcript sequences and may not capture all hybrid genes.
Digital Object Identifier (DOI)
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