Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo
2000
MIA Protein and Melanoma Metastasis
publication
Author Information
Author(s): Guba M, Bosserhoff A-K, Steinbauer M, Abels C, Anthuber M, Buettner R, Jauch K-W
Primary Institution: University of Regensburg; RWTH Aachen Medical School
Hypothesis
MIA plays a role in the metastasis of malignant melanomas.
Conclusion
Overexpression of MIA enhances the metastatic potential of melanoma cells without affecting primary tumor growth.
Supporting Evidence
- MIA protein is strongly expressed in advanced melanomas but not in normal melanocytes.
- MIA serum levels correlate with clinical tumor progression in melanoma patients.
- Enforced expression of MIA significantly increased metastatic potential in A-mel 3 cells.
Takeaway
MIA is a protein that helps melanoma cells spread in the body, but it doesn't change how big the original tumor gets.
Methodology
A-mel 3 melanoma cells were transfected with MIA cDNA and analyzed for changes in tumorigenic and metastatic potential.
Digital Object Identifier (DOI)
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