Partial Gastrectomy and Pancreatic Cancer Risk
Author Information
Author(s): P. Watanapa, B. Flaks, H. Oztas, P.H. Deprez, J. Calam, R.C.N. Williamson
Primary Institution: Royal Postgraduate Medical School, Hammersmith Hospital
Hypothesis
Does partial gastrectomy enhance pancreatic carcinogenesis?
Conclusion
Partial gastrectomy significantly increases the number and size of precancerous lesions in the pancreas.
Supporting Evidence
- Partial gastrectomy increased the number of acidophilic atypical acinar cell foci (AACF) from a median of 2.09 to 26.05.
- The volume of AACF increased nine-fold after partial gastrectomy.
- Basal plasma CCK concentrations were 46% higher in rats with gastrectomy compared to controls.
- Postprandial plasma CCK levels were significantly higher in gastrectomy rats at 5, 15, and 30 minutes after a fatty meal.
Takeaway
When part of the stomach is removed, it can make the pancreas more likely to develop cancer.
Methodology
Male Wistar rats underwent either partial gastrectomy or control surgery, followed by treatment with azaserine or saline, and were assessed for pancreatic lesions and CCK levels.
Limitations
The study was conducted in rats, which may not fully represent human responses.
Participant Demographics
Male Wistar rats weighing 250-300 g.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
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